The DNA sequence of living organism codes for RNA and it is referred to as gene. However, gene sequence alone cannot determine regulation of gene function. During development, signal response and disease manifestation, heritable chemical modifications of gene (DNA sequence) and its associated proteins such as DNA methylation, histone methylation, acetylation, phosphorylation etc. regulate the gene function on and above the gene. Therefore it is termed as “Epigenetics”. Epigentics is related to not only our tissue type but also to all activities including behaviour and ability to fight diseases. We do inherit some epigenetic modifications across generations and this phenomenon is referred to as ‘trans-generational Epigenetics’. But, most of the epigenetic modifications are trans-cellular and are closely linked to different diseases, which are not hereditary. Since epigenetics is reversible and highly regulated by the behaviour, diet and metabolism, microflora of any individual can fine tune the epigenetic response both in physiological and pathophysiological situations during the course of life. With the advancement of our knowledge regarding the molecular mechanisms of Epigenetics phenomenon, it is evident that even in the context of host-pathogen interactions the disease manifestation is only possible through the altered (favoured) epigenetic landscape influenced by the pathogens. Therefore, research in this area in a co-ordinated manner among the scientists from different areas of expertise including epigenetics, infectious diseases, metabolic disorders and microbiome fields would be highly productive and essential to understand the disease biology and exploit these knowledge for betterment of mankind. Therefore, this India-Japan seminar will be covering the discussion and research progress integrating the concepts of epigenetics-microbial infection-microbiomes. In this seminar, there will be 24 participants (12 experts and 12 students) from Japan, around 20 experts from India and also at least 75 Indian research fellows. The three days of discussion will be comprising not only of lectures from established scientists but also short talks and posters from young students. The students and the experts from diverse fields related to epigenetic diseases and microbiome will get an opportunity to interact and exchange their ideas. This will develop a strong research theme, related to both nations and also viable fruitful collaboration. The collaboration between India-Japan scientists are also expected to lead to several innovations which could be highly useful for developing diagnostics and therapeutics
The main topics to be covered in this India-Japan Conference are as follows:
a. Epigenetics and gene regulation
b. Epigenetic regulation of host-pathogen interaction
c. Bacterial infectious diseases
d. Regulation of chromatin dynamics by histone modifications and non-coding RNA.
e. Epigenetics and Cancer.
f. Epigenetic diseases and aging.
g. Epigenetics and Developmental Biology
h. Diversity of human microbiome, disease and therapy
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